Within the past two years there has been much work done in the various phases of mercuric chlorid poisoning. Before then, most of the work reported was of a therapeutic nature; but recently, new and important laboratory data have been contributed. These new data have certainly put the modern therapeutic measures to the test, discrediting many and placing a few on a firm basis.
The anatomic pathology has been well established. Every organ of the body is affected, the liver and kidneys bearing the brunt of the injuries. From a cloudy swelling the changes continue to fatty degeneration and necrosis. When the poisoning is severe, hemorrhagic inflammation may supervene.
Schamberg, Kolmer and Raiziss,1 in their studies of the comparative toxicity of the various preparations of mercury used for therapeutic purposes, have shown in a long series of dogs that every animal develops, evidences of nephritis of varying degrees after
WEISS HB. THE PRINCIPLES OF TREATMENT IN MERCURIC CHLORID POISONING: WITH RESULTS OF TREATMENT. JAMA. 1918;71(13):1045–1047. doi:https://doi.org/10.1001/jama.1918.02600390029008
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