No addition to the obstetric armamentarium during recent years has created so much attention and interest as the introduction of the solution of the active principles of the posterior lobe of the pituitary body, or hypophysis cerebri. Dale described its action on the uterine muscle in 1906, and later experiments by Frankl-Hochwart and Fröhlich showed that pituitary extract caused marked contraction of the uterus in pregnant animals. It was not until Blair Bell in 1909 employed these experimental results in practice that the therapeutic employment of the drug was begun. He used it in cases of postpartum hemorrhage and to reduce the bleeding in placenta praevia and cesarean section. The physiologic basis for the employment of the drug rests on the knowledge of its stimulating effect on all unstriped muscle tissues, including those of the blood vessels, intestine and bladder as well as the uterus, although it seems to have
KOSMAK GW. THE USE AND ABUSE OF PITUITARY EXTRACT. JAMA. 1918;71(14):1117–1120. doi:https://doi.org/10.1001/jama.1918.02600400017006
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