It has long been known that persons with defective hearts tolerate very badly such altitudes as those of Denver, Phoenix and Mexico City. Many instances have been quoted of serious and even fatal attacks of cardiac dilatation, pulmonary edema, etc., occurring within a few days after the arrival at these places. This popular view has, however, received up to the present very little confirmation from scientific work. Marked alterations in respiration have indeed been described; and the effects on the chemistry of the blood and tissues in reference to transport of oxygen have been studied in great detail. Beyond suggestions, however, that certain changes in blood flow might occur as the result of high altitudes, little evidence has been at hand that the effect on circulation is of great importance; especially there has been entire lack of proof of marked circulatory strain, or of the possibility of such disasters to
WHITNEY JL. III. CARDIOVASCULAR OBSERVATIONS. JAMA. 1918;71(17):1389–1391. doi:https://doi.org/10.1001/jama.1918.26020430011009b
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