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November 2, 1918


Author Affiliations

Interim Director of Surgery, Mount Sinai Hospital; Orthopedic Surgeon, Mount Sinai Hospital CLEVELAND

From the Surgical and Orthopedic Divisions of Mt. Sinai Hospital. Cleveland.

JAMA. 1918;71(18):1470-1475. doi:10.1001/jama.1918.02600440022007

The syndrome known as Little's disease was first brought to the attention of the profession by Little of London, who, in 1843, in a lecture before the London Orthopedic Institute, reported several cases of the disease, which since has borne his name.1 For a great number of years, this syndrome was erroneously classified as a medical entity, without any regard for the numerous causative factors. Since its etiology has been more completely recognized, it has been found that instead of its being a single medical entity, there are a great number of conditions with various etiologic factors, all producing the same end-results classified as Little's disease.

Cerebral spastic paralysis, or hemiplégie cérébrale infantile, seems a better term by which to express the manifestations of these various etiologic factors. The latter have been well classified by Grossman2 into three groups: 1. intra-uterine, or prenatal; (2) natal, or intrapartum, and

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