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November 16, 1918


JAMA. 1918;71(20):1660. doi:10.1001/jama.1918.02600460040011

In contrast with creatinin, creatin is not a normal constituent of the urine of healthy adult men, though it makes its appearance as the result of disturbance of metabolism. It may be found in the urine of women and is commonly excreted by children. These well substantiated facts offer a chemical and physiologic puzzle that has given rise to much speculation and considerable experimentation. The hypotheses advanced need not be detailed again here. They differ fundamentally in one respect, namely, as to whether the eliminated creatin is primarily of endogenous or exogenous origin. Rose has thus formulated the controversy: The acidosis theory of Underhill,1 and the carbohydrate deficiency theory as developed by Mendel and Rose,2 agree in attributing urinary creatin in individuals on a creatin-free diet to an entirely endogenous source, namely, the creatin of the tissues. The theory of McCollum and Steenbock3 and of Denis4