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Article
November 23, 1918

DISCONTINUANCE OF COMPATIBILITY TEST IN SERUM TREATMENT

Author Affiliations

Chelsea, Mass. Lieutenant-Commander and Lieutenant, Junior Grade, respectively, U. S. Navy.

JAMA. 1918;71(21):1765. doi:10.1001/jama.1918.02600470063026

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Abstract

To the Editor:  —Numerous inquiries concerning compatibility tests, etc., have led us to offer the following suggestions for informal publication:After consultation with reputable laboratory workers in Boston and New York, it was decided to discontinue the compatibility test of the donor's serum with the recipient's corpuscles. It would seem reasonable to believe that in all probability the donor's serum is so rapidly diffused and diluted in the blood stream that hemolysis and agglutination of a dangerous nature will not follow, whereas untoward reactions might result from introducing cells into a concentrated serum as in transfusion. Moreover, we have repeatedly given so-called "incompatible serums" to patients without the slightest untoward symptoms.Further experience has led us to pool the serum from our donors. This simplifies the preparation and the administration of serum, and apparently gives more uniform results.One of us, in a recent visit to New York, found physicians

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