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Global Health
March 17, 2015

Risk of HIV Infection Increases With an Injectable Hormonal Contraceptive

JAMA. 2015;313(11):1093. doi:10.1001/jama.2015.2061

The risk of HIV infection is moderately increased among African women who used the injectable hormonal contraceptive depot-medroxyprogesterone acetate, according to 2 recently published meta-analyses.

In an individual participant data meta-analysis, an international team of researchers examined 18 studies that measured hormonal contraceptive (HC) use and incident HIV infection among women aged 15 to 49 years living in sub-Saharan Africa (Morrison CS et al. PLoS Med. 2015;12[1]:e1001778). More than 37 000 women were involved in these studies, 1830 of whom became newly infected with HIV. Nearly half of the women were not using HC (the comparison group), 26% used depot-medroxyprogesterone acetate, 16% used combined oral contraceptives (COC), and 9% used norethisterone enanthate.