Various methods of local treatment have been tried in the therapy of anthrax. Among the measures used to destroy the pustule are, (1) excision, (2) the application of chemical or thermal cautery, and (3) the injection of germicides into the region of the pustule—such as tincture of iodin, phenol (carbolic acid), and a solution of mercuric chlorid. All these methods of treatment are objectionable, in that they either cause more or less extensive scar formation, the contraction of which often leads to disfigurement of the part, or are apt to produce toxic or poisonous symptoms, according to the substance injected. Excision has also the additional danger of laying open the blood and lymphatic channels so that symptoms of systemic infection may supervene, and the operation by no means always terminates the local process. Moreover, most of the methods, by their destructive action on the tissues, tend to increase sloughing, retard
REGAN JC. THE LOCAL USE OF ANTIANTHRAX SERUM IN TREATMENT OF ANTHRAX. JAMA. 1919;72(24):1724–1725. doi:10.1001/jama.1919.02610240012003
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