An attempt to unravel the mysteries of sympathetic ophthalmia has been made by Elschnig, following an idea of Bail, by regarding it as an anaphylactic phenomenon. To explain the onset of inflammation in the healthy eye, he has assumed an additional factor in a general disease or autointoxication, and asserts that since following out measures directed to relieving this toxic state, no cases of sympathetic ophthalmia have been observed at his clinic. While the anaphylactic theory, though offering many suggestive lines of thought, has been criticized by some, especially on clinical grounds, and corroborated by others, as in the excellent research work of Alan Woods, the solution of this problem is still far in the future, on account of the many difficulties that belong to a most intricate chapter in serology and immunology. It is therefore needless for me to enter into a discussion of these questions on the basis
KNAPP A. THE AUTOTOXIC FACTOR IN SYMPATHETIC OPHTHALMIA. JAMA. 1919;72(26):1897–1900. doi:10.1001/jama.1919.02610260017007
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