Malaria is recognized as one of the most serious of the disabling diseases of man. It is estimated that in India alone it causes on the average each year about 1,130,000 deaths and more than 100,000,000 cases of illness. The economic losses resulting from it are incalculable. The failure of the early Panama Canal project and the difficulties encountered in building the Madeira Railroad are only spectacular examples of what it is doing continuously and on an enormous scale to hinder industrial enterprise. On farming populations its burden falls with peculiar emphasis. Many of the richest agricultural lands in warm climates cannot be developed until the infection in these regions has been brought under control. The direct annual cost of the sickness and death that it produces in India alone is estimated at about $284,000,000; and this does not take into consideration the vastly greater losses due to the impaired
ROSE W. FIELD EXPERIMENTS IN MALARIA CONTROL. JAMA. 1919;73(19):1414–1420. doi:10.1001/jama.1919.02610450010003
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