The fact that the eyes of infants are almost invariably deep blue during the earliest weeks of life was recorded centuries ago. Modern investigations have furnished a clue to the explanation of the color changes in the iris during early infancy. The blue color is alleged to be due to the paucity of pigment in the stroma of the iris. This tissue is still very thin in early life, so that the posterior layer of pigment in the eye is plainly apparent through it. With increasing age, the stroma thickens. If no further pigmentation takes place in it, the iris tends to manifest a light blue or a gray shade; but when pigment is deposited in the iris layers, this organ becomes brown. Even in negro infants the iris may be blue in early life.
The progress of the changes of color shows some uniformity when large numbers of infants
THE COLOR OF THE IRIS DURING INFANCY. JAMA. 1919;73(19):1444–1445. doi:10.1001/jama.1919.02610450040015
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