In the early days of the roentgen-ray therapy of skin diseases, those who resorted to this mode of treatment employed it chiefly in certain cutaneous affections which, as a rule, were restricted in area, or were limited to certain well defined regions of the body, or occurred only as circumscribed or isolated lesions. For example, such affections as epithelioma and sarcoma, the various granulomas, keloid, ringworm of the hairy surfaces, and other diseases which did not readily respond to the older methods of treatment in common use at the time, would be, so to speak, consigned to the mercies of the roentgen ray, to reap the benefits of, or to suffer the evils from a subtle and powerful therapeutic agent, the precise nature and action of which is to this day unknown. Even in such relatively small and well defined lesions as basal cell epitheliomas, keloids, warts and circumscribed granulomas,
WISE F. ROENTGEN-RAY TREATMENT OF WIDESPREAD AND GENERALIZED DISEASES OF THE SKIN. JAMA. 1919;73(20):1491–1495. doi:10.1001/jama.1919.02610460009002
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