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November 22, 1919


JAMA. 1919;73(21):1579-1580. doi:10.1001/jama.1919.02610470015005

The most active measures used before the war against infectious diseases can be divided into three groups: (1) vaccines; (2) serums, and (3) specific chemical substances. According, then, to the measures employed, we practiced vaccinotherapy, serotherapy or chemotherapy. In the last few years a new form of therapy has been developed which has been called proteosotherapy or proteintherapy, according as one gives a proteose as a protein foreign to the internal medium (blood and lymph) such as the casein of milk. The characteristic feature of this method is the administration of the protein or proteose by a channel which avoids the action of the digestive juices; that is to say, by a parenteral route, subcutaneous, intramuscular or intravenous. Permit me to present to you briefly my experience with proteosotherapy, which I believe I was the first to use.

FIRST USE IN NONINFECTIOUS DISEASES  I used it first successfully in the

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