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Article
November 22, 1919

GANGRENE FOLLOWING AN INJECTION OF ARSPHENAMIN

JAMA. 1919;73(21):1611-1612. doi:10.1001/jama.1919.26120470001013

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Abstract

History.  —O. P. M., aged 35, married, an American laborer, family history negative, had his first attack of gonorrhea in 1903 and got over this in a short time. One year later he had a second attack, developing a double epididymitis, and was in the hospital five days. The next year he had a chancroid on the dorsum of the foreskin, which healed promptly. In June, 1917, when I saw him, he had a chancre on the right side of the shaft of the penis about 1 cm. from the pubis. I gave him an injection of 0.4 gm. of arsphenamin and a second one a week later. About one month after this his wife was in the hospital for a double pyosalpinx. She also had an ulcer the size of a dime on the anterior part of the cervix uteri. I gave her one injection of arsphenamin, after which

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