Extracts of the posterior lobe, or pars nervosa, of the pituitary structure provoke an unmistakable change in the secretion of urine when they are introduced directly into the circulation. This renal effect has been compared to the secretion-promoting effect exerted by extracts of the duodenum on the pancreatic cells. Because of such experimental observation the pituitary has been assumed to exercise a regulatory influence on the functions of the kidney. Such reasoning, often applied in connection with the ductless glands, has grave limitations and is rarely conclusive. As a recent writer has remarked, it is by no means logical to assume or infer that the functional importance of an organ is demonstrated by the properties of an extract of it. If one applies such an argument to the galactogogue substance in the pituitary of a fish, the absurdity is obvious.
Other evidence for the functional interrelation of kidney and pituitary
THE PITUITARY IN DIABETES INSIPIDUS. JAMA. 1919;73(21):1615–1616. doi:10.1001/jama.1919.02610470051017
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