[Skip to Content]
[Skip to Content Landing]
November 22, 1919


Author Affiliations

San Francisco.

JAMA. 1919;73(21):1629. doi:10.1001/jama.1919.02610470065027

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


To the Editor:  —I desire to advance a hypothesis as a serviceable conception of disease processes.Certain organisms or the toxins elaborated by them or poisons otherwise produced initiate specific processes in certain structures. These processes, if unchecked, run a definite course, and tend to produce characteristic symptoms. In many individuals so afflicted there comes a time in which the injured structures are sensitized not only to the specific proteins elaborated by the causal organisms, but also to allied proteins elaborated by other organisms, and perhaps to allied bodies chemically produced. In such instances the structural change already initiated tends to run as it would if the controlled original cause were still acting.Thus a tabetic, as a result of vigorous antisyphilitic treatment, may become symptomless, and his cerebrospinal fluid may be brought to normal; but if he should suffer from an infection, as acute appendicitis, the patient's chief and

First Page Preview View Large
First page PDF preview
First page PDF preview