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November 22, 1919


JAMA. 1919;73(21):1629. doi:10.1001/jama.1919.02610470065029

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To the Editor:  —Under the section devoted to N. N. R. (The Journal, Nov. 8, 1919, p. 1443), the action and uses of acriflavine are noted, with the fact that its clinical use has occasioned numerous and exceedingly conflicting published reports. My experience is that the preparation has no special virtue, compared to the usual nontoxic antiseptics, when employed in the cited indications. Acriflavine's chief value is its remarkable power to stimulate epithelial growth on healthy granulating surfaces. In cases in which Thiersch's method of skin grafting is indicated, as after amputation of the breast, I follow and recommend the practice of Mr. A. J. Couzens of London—wet eusol dressings for from twenty-four to thirty-six hours, then changing to wet acriflavine dressings, 1: 1,000. Healing occurs with great rapidity.

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