Aplastic or aregeneratory anemia is the term applied to a well marked type of anemia due to decreased blood formation. Clinically it is marked by anemia, a pronounced tendency to hemorrhage, and a rapidly fatal course. Despite the severity of the anemia there are none of the evidences of bone marrow regeneration, such as megaloblasts, normoblasts, anisocytes, and stippled or basophilic erythrocytes in the circulation. At necropsy the red marrow is found to be aplastic, showing an increase of fat and a diminution in megaloblasts and normoblasts.
The disease is not so rare. Musser1 collected reports of fifty-nine cases, including twenty-four of Cabot, and added another, which is probably the best studied case that has been reported.
The case that we present is reported on account of the remarkable opportunity it afforded for observing the progressive changes in the blood during the disease.
REPORT OF CASE
O'MALLEY JJ, CONRAD HB. THE COURSE OF THE BLOOD CHANGES IN A CASE OF APLASTIC ANEMIA. JAMA. 1919;73(23):1761–1764. doi:10.1001/jama.1919.02610490025011
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