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During the course of an investigation of the physiologic properties of the lipoid constituents of the various endocrine glands, a study of the effect of the anterior lobe of the pituitary body on the growth of the genital tract was undertaken. This work was completed in 1917, but for extraneous reasons has not been published until now.
Various investigators have obtained divers results from the feeding of the anterior lobe extracts to different varieties of animals, such as rats, rabbits and dogs. Among these investigators may be mentioned Sandri, A. E. Schaefer, T. B. Robertson and E. Goetsch. Robertson and Goetsch, the former using a purified extract which he denominates tethelin, and the latter the dry extract of the anterior lobe, claim to have obtained increase in body growth and stimulation of the genital tract in animals. The growth-producing effect of hypophysis extract appears to have been generally accepted in
FRANK RT. INFLUENCE OF PITUITARY EXTRACTS ON THE GENITAL TRACT. JAMA. 1919;73(23):1764–1765. doi:10.1001/jama.1919.02610490028012
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