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All practitioners of medicine, particularly those specializing in gastro-enterology, have patients with so-called "cardiorenal insufficiency" who complain of indigestion, of distressing flatulence, of sensations of epigastric fulness after eating, and of a general feeling of digestive discomfort. These patients may present valvular lesions in various stages of compensation: there may be arrhythmia or myocardial inefficiency or tumultuous heart action. The urine may be loaded with albumin, may show granular or hyaline casts or both, or at times it may be fairly normal. The questions of actual cardiac and renal pathology will not be discussed in this study, but rather the methods of steadying the heart's action, of aiding compensation, of allowing more physical space to the thoracic and abdominal organs, so that they may be less handicapped in performing their functions, and of lightening the work of the kidneys.
As a cardiac "steadier" plus a diuretic, I have much confidence
NILES GM. ALLEVIATION OF DISTRESSING DIGESTIVE SYMPTOMS IN "CARDIORENAL DISEASE"SOME SUGGESTIONS. JAMA. 1919;73(26):1932–1933. doi:10.1001/jama.1919.02610520022011
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