To the Editor The study by Dr Ikeda and colleagues1 on low-dose aspirin for primary prevention in patients who are at risk of cardiovascular events was stopped early for futility with regard to the primary outcome, which was “a composite of death from cardiovascular causes (myocardial infarction, stroke, and other cardiovascular causes), nonfatal stroke (ischemic or hemorrhagic, including undefined cerebrovascular events), and nonfatal myocardial infarction.”
Spence JD. Aspirin for Prevention of Cardiovascular Events in Older Japanese Patients. JAMA. 2015;313(14):1473. doi:10.1001/jama.2015.2574
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