To the Editor Dr Torres and colleagues1 reported that a substantial subgroup of patients with severe community-acquired pneumonia met criteria for septic shock and severe sepsis.2 The prevalence of septic shock was 23% (28/120).
A proportion of patients met severe sepsis criteria (68% [82/120]) based on having ratios of Pao2 to fraction of inspired oxygen of less than 250 mm Hg. Could the authors please clarify the volumes of fluid resuscitation administered to the methylprednisolone and placebo groups during the first 5 days after randomization?
Dominique J. Pepper. Treatment for Hospitalized Patients With Severe Community-Acquired Pneumonia. JAMA. 2015;313(21):2184. doi:10.1001/jama.2015.4774