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July 15, 1922


Author Affiliations


From the Medical Services and Electrocardiographic Laboratory, Michael Reese Hospital.

JAMA. 1922;79(3):187-194. doi:10.1001/jama.1922.02640030013005

Since the report by one of us (W. W. H.1) in December, 1921, of eight cases of auricular fibrillation in which quinidin sulphate was administered, we have observed and treated ten additional cases. In this paper we shall present (1) a further study of the cases previously reported; (2) the details of treatment and observation in ten new cases, and (3) the results and conclusions obtained from our experience with these eighteen cases in connection with a critical survey of the literature up to the present time.

In spite of lack of complete knowledge of the pharmacology of quinidin, its indications and contraindications in practice, and the occasional reports of serious untoward effects (paralyses, embolism and death), interest in its therapeutic use continues to grow. Reports and studies in quinidin therapy have appeared so fast during the past year, especially during the past six months, that it is well-nigh