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During the World War, the practice became common abroad of administering neo-arsphenamin in concentrated solutions in a small Luer syringe. This practice has likewise been adopted by many physicians in this country. It possesses the advantage of simplicity of administration and of time economy, factors which are important when large numbers of patients in clinics are treated.
When concentrated solutions are used with a Luer syringe, and even when larger quantities of water are employed, it is quite possible for minute fragments of glass dust, dust in the water or undissolved particles of the drug to be carried through the needle. Such particles, while not large enough to be readily visible to the eye, may still be of sufficient size to cause an embolism in the minute capillaries of the lungs or possibly other organs. It is probable that the nitritoid and similar immediate reactions which follow the administrations of
Schamberg JF. A FILTERING ADAPTER FOR THE ADMINISTRATION OF NEO-ARSPHENAMIN. JAMA. 1922;79(3):216–217. doi:10.1001/jama.1922.26420030001012c
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