[Skip to Content]
[Skip to Content Landing]
July 22, 1922


Author Affiliations


From the Section on Pediatrics, Mayo Clinic.

JAMA. 1922;79(4):285-286. doi:10.1001/jama.1922.02640040031010

The present study is concerned with an attempt to determine the direct mode of action of several of the more commonly used drugs in the treatment of pyelitis. The action of the alkalis, of hexamethylenamin and of phenyl salicylate has been studied.

First, it must be said that pyelitis, in most instances, is a self limited disease, which may disappear almost as rapidly as it appears. It is sometimes discovered accidentally by routine examination of the urine. At other times, it may be associated with very severe symptoms, being, even, rapidly fatal, owing to renal complications. Our inability to distinguish between pyelitis with and without renal involvement makes it extremely difficult to differentiate, at the onset, the severe from the mild; at present, the clinical course is the sole criterion. This difficulty practically rules out the possibility of comparing the various modes of treatment by studying a given number of