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August 5, 1922


JAMA. 1922;79(6):477-478. doi:10.1001/jama.1922.02640060059016

The remarkable constancy in the composition of the important tissues and fluids within the organism must excite a never-failing interest in any one who studies the fundamental physiologic processes. Regulatory functions are continually being brought into play to secure the uniformity referred to. The various adjustments and adaptations evidently acting to secure a proper arterialization of the blood under the changing condition of atmosphere and tissue needs for oxygen have often been cited in The Journal. An equally effective regulation seems to occur in connection with the behavior of water in the body. The variations in intake may be very large, the amount and paths of the output may also show large irregularities depending on a number of unlike circumstances; yet in health the water balance of the body seems to result in a distribution of the "universal solvent" that averts undue concentrations or dilutions wherever an opportunity for the