The investigations of Rettger and Cheplin1 have shown that B. acidophilus actually accomplishes much that Metchnikoff expected of B. bulgaricus, which has failed to fulfil its promise. They have described the satisfactory treatment of chronic constipation and diarrhea with milk fermented by B. acidophilus reinforced with lactose.2 It is well known that patients in institutions commonly suffer from chronic constipation. The present investigation, therefore, was undertaken, at Dr. G. H. Kirby's suggestion, in order to ascertain the benefits, if any, to be derived by psychotic patients from such treatment.3 In a sense this represents one aspect of the major problem under consideration, namely, the relation of focal infection to the functional psychoses (which has been reported elsewhere4). Some of the methods employed at the New Jersey State Hospital at Trenton, N. J., for the determination and treatment of focal infections have been subjected by us to
KOPELOFF N, CHENEY CO. STUDIES ON THE THERAPEUTIC EFFECT OF BACILLUS ACIDOPHILUS MILK AND LACTOSE: PRELIMINARY COMMUNICATION. JAMA. 1922;79(8):609–611. doi:10.1001/jama.1922.02640080011004
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