In a note published two years ago, Newburgh and Squier1 reported the occurrence of atherosclerosis in two small groups of rabbits, eleven in all, that had been fed high protein diets. While the evidence at hand indicated that the vascular lesion had been caused by the diets, such a conclusion was not safe because the experiments were too few to permit a generalization.
The present communication is an abstract2 of the further investigation of the effect of high protein diets on the arteries of rabbits.
The term atherosclerosis, as used by most pathologists, is intended to designate a primary disease of the intima and to exclude lesions of the intima which result from disease of the media or vasa vasorum. The gross and histologic characteristics of this primary intimal disease are so well known to this group that further description is unnecessary.
Two series of animals have been
NEWBURGH LH, CLARKSON S. PRODUCTION OF ARTERIOSCLEROSIS IN RABBITS BY DIETS RICH IN ANIMAL PROTEINS. JAMA. 1922;79(14):1106–1108. doi:10.1001/jama.1922.02640140018007
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