Sickle cell anemia was first described, fourteen years ago, by Herrick.1 Subsequent observers, up to a year ago, had reported only three additional cases.2 Last year, I reported observations on eleven instances occurring in two families;3 a simultaneous report by Huck 4 recorded seventeen cases found in three families. Our series at the present time comprises eighty cases. All of the reported instances have occurred in negroes.
Sickle cell anemia is a familial and hereditary disease showing no sex preference and probably confined to the negro race. Our series includes ten family groups; in fact, in every case in which it has been possible to examine the relatives of patients with this condition, a familial incidence has been found. The disease is present and recognizable at birth; on two occasions, blood from the cord and from the proper circulation of infants of "sickle cell" mothers has been
SYDENSTRICKER VP. FURTHER OBSERVATIONS ON SICKLE CELL ANEMIA. JAMA. 1924;83(1):12–17. doi:10.1001/jama.1924.02660010016004
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