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October 7, 1922


Author Affiliations


JAMA. 1922;79(15):1221-1224. doi:10.1001/jama.1922.02640150033008

Achylia gastrica was first described by Fenwick1 in 1877. He then reported four cases that were undoubtedly progressive pernicious anemia characterized by a yellow discoloration of the skin, the absence of free hydrochloric acid in the gastric contents, the probable absence of ferments in the gastric contents as indicated by the undigested condition of the food, and a rapidly progressive and fatal course. He called these cases atrophy of the gastric mucous membrane. Quincke, Jaworski2 and others studied the condition at the same time. The literature is considerable; but, on the whole, it cannot be said that achylia gastrica has excited any great degree of attention on the part of the medical profession. This has been largely due to the fact that it is often merely a complication of certain other conditions, such as carcinoma, progressive pernicious anemia and amyloid disease, and that very often it may exist