Following a preliminary report in February, 1915,1 there is here presented a detailed study of seventy-five cases of systemic infections complicating or accompanying middle ear disease. The cases are limited to those which came to operation, so that the pathologic conditions presented may be studied in relation to the clinical course, laboratory findings and roentgen-ray examinations. These observations lead to a definite grouping of the cases, each group being a distinct clinical entity, at once defined and comprehensible. Not only does the reclassification of these systemic infections, based on observed pathologic changes, make diagnosis more exact; but it also furnishes us with a more logical basis for the therapy and the management of the given case belonging to one or the other group. It will likewise clarify, and in the future obviate, the great amount of confusion evident in the current literature, wherein case reports of typical and atypical
KOPETZKY SJ. SYSTEMIC INFECTION COMPLICATING PURULENT MIDDLE EAR DISEASE. JAMA. 1924;83(5):336–343. doi:10.1001/jama.1924.02660050022005
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