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August 9, 1924


JAMA. 1924;83(6):453-455. doi:10.1001/jama.1924.02660060057023

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Attempts to Immunize Against Tuberculosis  Dr. Calmette, assistant director of the Pasteur Institute, presented recently to the Academy of Medicine a communication on immunization against tuberculosis. In collaboration with Drs. C. Guérin, Weill-Hallé and others, he has succeeded in conferring on young animals free from preexisting tuberculosis an immunity to tuberculous infection, by utilizing as a vaccine the living culture of a bacillus of bovine origin artificially attenuated and deprived of all tuberculigenous capacity.In order to attenuate the virulence of this bacillus, Calmette and his collaborators used a method never previously employed. This consisted in cultivating the tubercle bacillus in uninterrupted series in an ox-bile medium, in order to modify hereditarily its physicochemical constitution, by accustoming it to develop in an extremely alkaline medium and one particularly rich in lipoids. Potatoes boiled in ox-bile to which 5 per cent. glycerin had been added were used as the medium. After

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