In a previous communication, one of us1 drew attention to the possible rôle of the variable ph of sodium citrate in the causation of untoward results in transfusion by the citrate method. We wish here to emphasize further our position in regard to the relation of the ph factor to reactions following intravenous injections in general. As indicated in our paper, the proposition of imitating as closely as possible the ph of the blood by buffering intravenous solutions was by way of suggestion, since it seemed to be a logical procedure. It was distinctly stated then that no claims were made for its efficacy, and none are made now. Such claims can come only from experimental work or from carefully controlled clinical studies.
In the literature of blood transfusion there are numerous attempts to account for the occurrence of more or less severe reactions when careful preliminary tests had
MELLON RR, HASTINGS WS, CASEY GU. OBSERVATIONS ON THE EFFECT OF SODIUM CITRATE ON THE BLOOD: ESPECIALLY CONSIDERING THE ph FACTOR. JAMA. 1922;79(20):1678–1681. doi:10.1001/jama.1922.02640200028010
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