In May, 1923, in collaboration with Long, one of us 1 reported on some results obtained in animals with the toxin of botulism. Our findings, in brief, were that in all cases there was a more or less complete curare-like action on the endings of the motor nerves to the voluntary muscles, producing a certain degree of paralysis of the muscles. The phrenic nerves also being affected, the paralysis involved the diaphragm early, the life of the animal being maintained by the accessory respiratory muscles until they too became so weakened that they could not function adequately, and consequently failure of the respiration closed the picture. Complete paralysis of the motor nerves was not present in all cases, but even in those nerves the stimulation of which would result in a motor response, the curare-like action was still to be seen in the early fatigue of the nerve, a phenomenon
EDMUNDS CW, KEIPER GF. FURTHER STUDIES ON THE ACTION OF BOTULINUS TOXIN. JAMA. 1924;83(7):495–502. doi:10.1001/jama.1924.02660070011006
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