In 1910, Woodyatt1 suggested, in explanation of the ketolytic action of glucose, that 1 molecule of acetoacetic acid might react with 1 molecule of alcohol or glucose and thus undergo oxidation at the expense of the simultaneous reduction of the glucose. This assumption was based on analogy with the observed behavior of ketones and alcohol when these were exposed to bright sunlight, as had been reported by Cimician and Silber, and is in harmony with what is known of the behavior of the acetone bodies in metabolism. Although Geelmuyden 2 can be credited with an earlier hypothesis of intermolecular chemical reaction between the acetone bodies and glucose, Woodyatt was responsible for stimulating much of the investigation of this subject. Geelmuyden proposed a conjugation of glucose and the acetone bodies, a view with which Ringer's 3 hypothesis of ten years later harmonized.
The demonstration by Shaffer,4 in 1921, of
WILDER RM. "OPTIMAL" DIETS FOR DIABETIC PATIENTS. JAMA. 1924;83(10):733–737. doi:10.1001/jama.1924.02660100007003
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