For test preparations we use the uterus of the rat; also segments of the rat's small intestine, chiefly the duodenum. The use of the rat's uterus for physiologic and pharmacologic purposes has been quite limited, although it is admirably adapted to the purposes. The rabbit and the guinea-pig have heretofore been the standard animals for this type of experimentation, but preparations from the rat are better.
Isolated segments of the rat's uterus, prepared by taking the horn and half the body of the organ, and mounting the right and left preparations in duplicate, constitute unique test preparations. The segment should be mounted in a balanced mammalian salt solution, kept at body temperature, and constantly and evenly oxygenated. We have set up the preparations in Harvard warm chamber tubes, so arranged that a change of solution can be promptly and deftly made without disturbing the tension conditions. These tubes are mounted
GREENE CW, BONHAM CD. SOME POINTS IN THE PHYSIOLOGY OF SMOOTH MUSCLE AND ITS NERVE REGULATION. JAMA. 1924;83(11):840–841. doi:10.1001/jama.1924.02660110038011
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