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September 20, 1924


Author Affiliations

From the Gynecological Department of the Johns Hopkins Medical School.

JAMA. 1924;83(12):900-906. doi:10.1001/jama.1924.02660120016004

The investigations of Hitschmann and Adler,1 which have been confirmed in all essential respects by subsequent workers, have established quite definitely the histologic changes occurring in the endometrium at various phases of the menstrual cycle. There is little or no difference of opinion at the present day concerning the histologic characteristics of the postmenstrual, the interval, and the premenstrual stages. With reference to the menstrual phase, i. e., the phase of actual menstrual bleeding, opinion is not nearly so unanimous. Knowing the picture just before the onset of the period as well as that found just after its close, one might logically assume that the chief feature of the menstrual phase is a transition from the premenstrual high point of development to the low point so characteristic of the postmenstrual phase. Since both the premenstrual and the postmenstrual stages are characterized by an intact endometrial surface, one might further