From time to time, specific physiologic rôles that may be assumed by the different amino-acids that have of late acquired prominence in the biochemistry of the tissues and fluids of the body are being discovered. Most obvious is the association of cystinuria with the amino-acid protein derivative cystin when the latter fails of complete destruction in metabolism. Alkaptonuria has similarly become associated with the tyrosin complex of the albuminous substances; while the aminoacid tryptophan may become responsible for the production of indol and related compounds in the organism. When benzoic acid or its derivatives are ingested, the appearance of hippuric acid (benzoyl glycin) in the urine calls attention to the detoxicating effect of the amino-acid glycocoll. Many of the disintegration products of proteins fail to come to notice readily because they are so easily oxidized to simple endproducts. The cyclic derivatives, such as those containing the benzene ring or "aromatic
HISTIDIN AND ITS DERIVATIVES IN THE BODY. JAMA. 1924;83(12):924–925. doi:10.1001/jama.1924.02660120040015
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