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December 16, 1922


Author Affiliations

Rochester, Minn.

JAMA. 1922;79(25):2104. doi:10.1001/jama.1922.02640250058031

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To the Editor:  —While a member of the John McCormick Institute for Infectious Diseases, Chicago, I discovered that antibodies appear more rapidly in the blood following the injection of partially autolyzed pneumococci ("pneumococcus antigen") than following the injection of heat-killed pneumococci.Through the cooperation of Dr. Ludvig Hektoen, director of the institute, and of physicians at the Presbyterian and Cook County hospitals, the effect of this antigen on the course of lobar pneumonia, as compared with alternate untreated cases, was studied for three consecutive years. The mortality rate was lower in the treated than in the control series. Subsequent studies have corroborated these results.During my studies on the bacteriology of influenza in 1918-1919, I prepared, from the freshly isolated strains of bacteria, mixed vaccines which appeared to be valuable in prophylactic inoculation against the more serious respiratory infections in influenza.The burden of the preparation and distribution of these

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