Today it is accepted that the glands of internal secretion have a profound influence on the growth of the body, its development, including the secondary sex characters, the rate of metabolism and other important functions. Laboratory experiments and clinical observation have established opinions in regard to the normal and pathologic physiology of the ductless glands which are satisfactory to many endocrinologists, but which are not accepted by all physiologists and by some clinicians. Among these beliefs or opinions are that:
1. The actions of some of the glands of internal secretions are correlated and, therefore, certain physiologic processes are pluriglandular activity effects. 2. The action of some of the glands of internal secretion is reciprocal, in that some of the glands may become for a time reciprocally operative to compensate for some other undersecreting gland. 3. The alleged reciprocal and correlated action of the glands is explained on the theory
BILLINGS F. GLANDULAR THERAPY: INTRODUCTION. JAMA. 1924;83(13):1000–1001. doi:10.1001/jama.1924.26610130003013
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