The study of industrial efficiency in connection with the prosecution of the World War tended to accentuate certain aspects of human welfare that had until then attracted little consideration. Environmental conditions, such as temperature, humidity, ventilation and food resources, long believed to play a part in the determination of human comfort and physical well-being as well as muscular efficiency, were subjected to new examinations and evaluation with respect to their possible bearing on fatigue or overfatigue. The avoidance of excessive fatigue became the keynote of various preventive measures in which human health and activity were concerned. Incidentally, the conviction gained ground that fatigue plays a significant part in the causation of disease; thus, Sir James Paget is quoted as writing: "You will find that fatigue has a larger share in the promotion or transmission of disease than any other single causal condition you can name."1
In preventive medicine, mere
FATIGUE AND RESISTANCE TO DISEASE. JAMA. 1922;79(26):2165–2166. doi:10.1001/jama.1922.02640260037017
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