The trend of the normal processes of metabolism is to produce acid substances, so that the problem of neutrality regulation involves, above all, effective elimination of acids. In acidosis, this capacity may become jeopardized. Owing largely to the writings of D. Wright Wilson and his co-workers,1 the view has gained ground that at times there may arise a condition designated as alkalosis, in which the blood and consequently other tissue fluids attain an unduly alkaline condition. There is here an implication, at least, of an increase in the hydroxyl ions of the blood as an expression of the abnormal variation in the acid-base balance of the circulating medium. It has further been taught that at such a juncture there is a hyperexcitability of the neuromuscular mechanisms of the body, which may frequently be demonstrated by the lowered threshold of electric stimulation, and may even result in manifest tetany. Wilson
THE ALLEGED RELATION BETWEEN ALKALOSIS AND TETANY. JAMA. 1922;79(27):2232–2233. doi:10.1001/jama.1922.02640270030019
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