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Article
October 11, 1924

GLANDULAR THERAPY: THE PHYSIOLOGY OF THE THYROID GLAND

JAMA. 1924;83(15):1165-1166. doi:10.1001/jama.1924.26610150005014
Abstract

"The thyroid acts on oxidation as a pair of bellows rejuvenates a fire" (von Noorden, 1912). The active principle, thyroxin, has been isolated and its chemical formula determined as being a derivative of tryptophan, containing 65 per cent. of iodin (E. C. Kendall, 1914). Thyroxin "is a catalyst that accelerates the formation of a quantum of potential energy in the cells of the organism" (Plummer, 1915). The colloid contained within the vesicles of the thyroid gland is believed to be the only vehicle for storing this active substance in an inert manner (Marine). According to Marine a thyroid that contains less than 0.1 per cent. of iodin cannot be normal anatomically, and a thyroid that has continuously had an iodin store above 0.1 per cent. cannot be abnormal anatomically. As early as the twelfth century, goitrous enlargements of the thyroid were treated with iodin-containing sponges and seaweeds by Roger of

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