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February 3, 1923


JAMA. 1923;80(5):293-299. doi:10.1001/jama.1923.02640320005002

During the investigation, study and teaching of nephritis and allied conditions, there have come under our observation and been available for hospitalization or accurate control in the office numerous cases of so-called orthostatic or variable albuminuria, which have been made the subject of a special study. In our experience, every case of orthostatic albuminuria, with very rare exceptions, will become and remain albumin free, regardless of posture, exertion, time of day or urinary concentration, as long as the urine remains neutral or slightly alkaline. In three cases, alkalization failed to prevent the appearance of albumin, and, at present, we believe that, while there was no evidence of renal disease demonstrated, these cases include some slight or early element of nephritis, or belong to the group later referred to as "leaky kidneys." However, we do not claim that every case of pure orthostatic albuminuria will necessarily respond to alkalization by becoming