[Skip to Navigation]
Sign In
November 8, 1924


Author Affiliations

From the Durand Hospital of the John McCormick Institute for Infectious Diseases.

JAMA. 1924;83(19):1498-1500. doi:10.1001/jama.1924.02660190030010

Within the last year, there have been reported in Germany1 about a dozen cases of a most interesting condition, grave ulcerative angina associated with extreme leukopenia. This syndrome has been called agranulocytosis, or agranulocytic angina, and as far as reported the symptoms are remarkably similar in all instances. Women of middle age are affected, and the disease is fatal after a fairly acute course. The onset is sudden, with fever and sore throat. The characteristic lesions are rapidly spreading ulcers, invariably present on the tonsils and pharyngeal walls, often on the gums, larynx, tongue and about the genitalia. There is little or no enlargement of the regional lymph glands; in fact, there seems to be little reaction of any sort to the lesions, and no resistance to their rapid spread. Icterus, without obvious cause, occurs in a majority of the patients. A hemorrhagic diathesis is not usually part of

Add or change institution