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Stejskal has furnished us a diligent outline of what is known about "osmotherapy." Under this heading might be included all those remedial measures that act chiefly by producing osmotic changes. In the widest sense, hypotonic as well as hypertonic measures, local as well as systemic in action, would properly be classified under it. This book, however, deals chiefly with the study of the changes produced by intravenous injection of hypertonic solutions, especially of dextrose, as no other substance can be injected in such dose and concentration. The greater part of the book is occupied with an exhaustive discussion of the theoretical and experimental foundation of this procedure, which is so recent in origin that the first attempts at it date from 1884. Prior to this, hypertonic infusion was considered too dangerous to be employed in the human body. Since then a voluminous literature on the subject has become available, and
Grundlagen der Osmotherapie. JAMA. 1923;80(5):350. doi:10.1001/jama.1923.02640320062037
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