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For the last two years, all cases of hiccup coming under my observation, more particularly after operation, have been treated by the intramuscular injection of 25 or 30 minims of ether. Dr. Allen M. Thomas of New York called my attention to its use in children for stopping the paroxysms of whooping cough, and it occurred to him that it might likewise be useful in the paroxysm of hiccup. If the original dose is not immediately successful, it is repeated one or more times at several hours' interval. Its administration is not painful, and has never been attended with unpleasant circumstances.
The first patient on whom I tried it was an elderly and feeble man who, shortly after a gastro-enterostomy for pyloric stenosis, developed hiccup of moderate severity but of great persistency. The other time-honored remedies had no effect. After the first administration of ether, the hiccups diminished in severity
Gibson CL. ETHER INTRAMUSCULARLY FOR THE RELIEF OF HICCUP. JAMA. 1923;80(6):399. doi:10.1001/jama.1923.26430330003015c
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