While it is true that albuminuria does not always denote renal disease, the inescapable fact remains that albuminuria is almost always the earliest sign of nephritis; and it is generally discoverable months or even years before the symptomatology, the blood chemistry or the most sensitive of renal function tests become diagnostic.1 Neither clinical nor insurance medicine has as yet taken as thorough cognizance of the importance of minimal amounts of albumin or of the relation of dilution of the specimen to amount of albumin as statistics justify, and chiefly because the albumin tests in common use do not enable one to make precise distinctions between truly persistent and genuinely intermittent albuminurias.
VALUE OF VARIOUS TESTS
As a matter of technical practice, we are accustomed to the use of criteria which are not truthfully informative. For instance, if one uses Heller's test as the criterion, as many do, one is
EXTON WG. A SIMPLE AND RAPID TEST FOR ALBUMIN AND OTHER URINARY PROTEINS. JAMA. 1923;80(8):529–530. doi:10.1001/jama.1923.02640350011005
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