The statement by Widal, Abrami and Iancovesco,1 in 1920, that leukopenia following a standard protein meal is to be regarded as a delicate test for the presence of hepatic insufficiency suggested the advisability of studying a series of postalimentary leukocyte curves in normal persons. As the original article by Widal and his co-workers reported only eleven control experiments, it seemed wise to try the test further on a larger group of healthy men.
Widal's test appears to rest on a sound experimental basis. It is known that the injection of a certain quantity of commercial peptone into the general circulation of a dog will promptly result in a crise hémoclasique. This syndrome is an evidence of upset of the colloidal balance of the blood, and is characterized clinically by leukopenia, a fall of blood pressure, hypercoagulability, and a change in the refractive index of the serum.
If after a
FEINBLATT HM. ALIMENTARY LEUKOCYTOSIS IN EIGHTY NORMAL MEN: A STUDY IN REFERENCE TO THE CRISE HÉMOCLASIQUE OF WIDAL. JAMA. 1923;80(9):613–615. doi:10.1001/jama.1923.02640360021007
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