Our knowledge of the action of extracts of the ovaries is in a highly unsatisfactory condition, although recently some progress has been made in solving some of the problems in connection therewith. The difficulties connected with the work are not hard to understand. In the first place, the ovary contains more than one structure which might be capable of elaborating a hormone. We have to consider the ovary as an entity; also the corpus luteum or the ovary without the corpus luteum; and, finally, the liquor folliculi, to say nothing of the much discussed interstitial cells. We have to consider the juices expressed from the ovary or watery extracts of the ovary, alcoholic extracts and lipoid extracts—all of which have been employed in experimental work. Finally, there has been until recently the difficulty connected with the obtaining of accurate criteria for measuring the activity of these various preparations on the
EDMUNDS CW. THE PHARMACOLOGY OF OVARIAN PREPARATIONS. JAMA. 1924;83(25):2016. doi:10.1001/jama.1924.26610250002014
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